TRANSCRIPTOMIC PROFILING REVEALS MOLECULAR PATHWAYS IN NEWCASTLE DISEASE VIRUS INFECTED ASEEL CHICKEN EMBRYOS

Authors

  • M. Muthusamy Tamil Nadu Veterinary and Animal Sciences University (TANUVAS), Namakkal, India.
  • M. F. Oladipo University of Jos, Nigeria
  • A. K. Thiruvenkadan College of Poultry Production and Management, TANUVAS, Hosur, India.
  • C. Ramasamy Veterinary and Animal Sciences University (TANUVAS), Namakkal, India.
  • O. M. Akinsola Department of Theriogenology and Production, University of Jos, Nigeria .

DOI:

https://doi.org/10.51791/njap.vi.8706

Keywords:

Aseel, NDV infection, Gene Ontology, KEGG

Abstract

Transcriptomic study of lung tissue from Newcastle disease Virus (NDV) infected Aseel chicken embryos revealed 135 differentially expressed genes (DEGs) with p-values < 0.05. Subsequent study found that NDV infection caused significant changes in four Gene Ontology (GO) terms and 19 Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathways. Understanding these GO enriched terms and KEGG pathways in the context of NDV-infected embryo is critical for better understanding the disease molecular processes and metabolic disruptions. This understanding underlines the virus's effect on host metabolism and immunological responses, which may help identify treatment targets or vaccine development strategies.

Author Biographies

M. Muthusamy, Tamil Nadu Veterinary and Animal Sciences University (TANUVAS), Namakkal, India.

Department of Animal Genetics and Breeding, Tamil Nadu Veterinary and Animal Sciences
University (TANUVAS), Namakkal, India.

M. F. Oladipo, University of Jos, Nigeria

Department of Theriogenology and Production, University of Jos, Nigeria

A. K. Thiruvenkadan, College of Poultry Production and Management, TANUVAS, Hosur, India.

College of Poultry Production and Management, TANUVAS, Hosur, India.

C. Ramasamy, Veterinary and Animal Sciences University (TANUVAS), Namakkal, India.

Department of Animal Genetics and Breeding, Tamil Nadu Veterinary and Animal Sciences
University (TANUVAS), Namakkal, India.

O. M. Akinsola, Department of Theriogenology and Production, University of Jos, Nigeria .

Department of Theriogenology and Production, University of Jos, Nigeria

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Published

2025-03-20

How to Cite

Muthusamy, M. ., Oladipo, M. F., Thiruvenkadan, A. K. ., Ramasamy, C. ., & Akinsola, O. M. . (2025). TRANSCRIPTOMIC PROFILING REVEALS MOLECULAR PATHWAYS IN NEWCASTLE DISEASE VIRUS INFECTED ASEEL CHICKEN EMBRYOS . Nigerian Journal of Animal Production, 58–61. https://doi.org/10.51791/njap.vi.8706

Issue

2025: Proceedings 2025

Section

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