EVALUATION OF SODIUM GLUTAMATE INDUCED DIABETIC GUINEA PIG TREATED WITH Momordica charantia ON LYMPHOID ORGAN RESPONSES

Abstract

This study investigated the effects of sodium glutamate and Momordica charantia (bitter melon) on the lymphoid organs of induced Diabetic guinea pigs. The guinea pigs were randomly allotted to four dietary treatment T1, T2, T3, and T4 compromising of 6 guinea pigs treatment and replicated thrice with two guinea pigs per replicate. After eight weeks of treatment, the 2 guinea pigs from each treatment were euthanized and their spleen, bile, kidney, heart and lungs were collected and weighed. The results showed Effect of sodium glutamate induced Diabetic guinea pig treated with Momordica charantia on lymphoid responses. The key findings indicated that there were no significant differences in liver (insert value), spleen (insert value) kidney, bile, and heart weight. The gross anatomical and pathological lesions observed shows that T4 had the highest occurrence of pathological changes in lymphoid organs and hepatic tissues was observed to have no fluid accumulation, pus, and odor while kidney and lungs were found to have necrosis, swollen and heamatoma. It was observed that liver was looking excessively dark brown in color in most of the treatment. Momordica charantia were found to have profound effect on hepatocytes, hepatocytes height, cholangiocytes, kuffers cells, endothelial cells and sinusoids.