EFFECT OF MALIGNANT HYPERTHERMIA USING SEVOFLURANE GAS ON VITAL SIGNS OF CAVIA PORCELLUS (GUINEA PIG)

Abstract

This study assessed the effects of sevoflurane gas on the vital signs of Cavia porcellus with experimentally induced malignant hyperthermia. For the determination of malignant hyperthermia, 50 Cavia porcellus were placed in an anesthesia chamber for 5 minutes and subjected to a mixture of air with 3% sevoflurane gas. Only 6% of them reacted positively, while most of them, 94%, were negative. The average body temperature of the positive kits was 38.9ºC, oscillating between 38.7 and 39.1 ° C, while the negative ones averaged 37.9 ° C. The positive kits had an average of 142.3 breaths per minute compared to the negative ones, which was determined to be 83.7. The number of heart beats per minute in the kits with a positive reaction to sevoflurane averaged 205 and the negative ones 119.5. It was concluded that for every 16 guinea pigs, one will react to the sevoflurane gas exposure positively based on the result obtained from the vital sign. Only the positive ones presented muscle tremors.